Midland hawthorn (Crataegus oxyacantha) is a shrub common in Eurasia and northern Africa, its medicinal raw material are: inflorescence with leaves (Inflorescentia crataegi) and fruit (Fructus crataegi), a rich source of flavonoids (including apigenin, vitexins, isovitexins and their glycoside bindings), choline, organic acids (such as coffee, chlorogenic), esculin (that belongs to the coumarins), triterpenes and vitamin C. Preparations of Crataegus oxyacantha have a strengthening effect on the heart, regulate blood pressure and myocardial intercellular tension, calming the nervous system, antispasmodic for intestines smooth muscle, uterus and blood vessels, analgesic. Flavonoids have an impact on the nutrition of brain cells. A special and useful feature is slow and gentle action, ensuring the effectiveness and lack of side effects. Supplements containing medical materials of Crataegus oxyacantha.